中/英文名称：

ABL2蛋白抗体/   Anti- ABL2

别名：

Abelson murine leukemia viral oncogene homolog 2;   Abelson related gene protein; Tyrosine kinase ARG; ABLL;ARG;Tyrosine protein   kinase ABL2; v abl Abelson murine leukemia viral oncogene homolog 2;   ABL2_HUMAN; Abelson tyrosine-protein kinase 2; Tyrosine-protein kinase ARG.

产品编号：

zy10009

规格：

0.1ml   0.2ml

抗体来源：

Rabbit

浓    度：

1mg/ml

缓冲液：

0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium   azide；Reconstitute with 0.1ml sterile distilled water.

克隆类型：

Polyclonal

亚 型：

IgG

免 疫 原：

KLH conjugated synthetic peptide derived from   human ABCG1

交叉反应：

Human, Mouse, Rat, Dog, Pig, Horse, Rabbit

状态：

Lyophilized or Liquid

分 子 量：

Predicted molecular weight 120kDa

纯化方法：

affinity purified by Protein A

运输与储存

运输:

The product is shipped at ambient temperature.   Upon receipt, store it immediately at the temperature recommended below.

储存:

Use a manual defrost freezer and avoid repeated   freezethaw cycles.

1 month from date of receipt, 2 to 8℃, reconstituted.

6 months from date of receipt, -20 to -70℃, reconstituted.

12 months from date of receipt, -20 to -70℃as supplied.

When reconstituted in sterile pH 7.4 0.01M PBS or   diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

产品应用

应用:

WB=1:100-500 ELISA=1:500-1000 IP=1:20-100   IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500
  Not yet tested in other applications.
  Optimal working dilutions must be determined by the end user.

背景:

This gene encodes a member of the Abelson family   of nonreceptor tyrosine protein kinases. The protein is highly similar to the   c-abl oncogene 1 protein, including the tyrosine kinase, SH2 and SH3 domains,   and it plays a role in cytoskeletal rearrangements through its C-terminal   F-actin- and microtubule-binding sequences. This gene is expressed in both   normal and tumor cells, and is involved in translocation with the ets variant   6 gene in leukemia. Multiple alternatively spliced transcript variants   encoding different protein isoforms have been found for this gene. [provided   by RefSeq, Nov 2009]

其他：

ABL-2属Abelson（白血病病毒）家族的非受体酪氨酸激酶，目前主要用于恶性肿瘤的研究。

Function:

Non-receptor tyrosine-protein kinase that plays   an ABL1-overlapping role in key processes linked to cell growth and survival   such as cytoskeleton remodeling in response to extracellular stimuli, cell   motility and adhesion and receptor endocytosis. Coordinates actin remodeling   through tyrosine phosphorylation of proteins controlling cytoskeleton   dynamics like MYH10 (involved in movement); CTTN (involved in signaling); or   TUBA1 and TUBB (microtubule subunits). Binds directly F-actin and regulates   actin cytoskeletal structure through its F-actin-bundling activity. Involved   in the regulation of cell adhesion and motility through phosphorylation of   key regulators of these processes such as CRK, CRKL, DOK1 or ARHGAP35.   Adhesion-dependent phosphorylation of ARHGAP35 promotes its association with   RASA1, resulting in recruitment of ARHGAP35 to the cell periphery where it   inhibits RHO. Phosphorylates multiple receptor tyrosine kinases like PDGFRB   and other substrates which are involved in endocytosis regulation such as   RIN1. In brain, may regulate neurotransmission by phosphorylating proteins at   the synapse. ABL2 acts also as a regulator of multiple pathological signaling   cascades during infection. Pathogens can highjack ABL2 kinase signaling to   reorganize the host actin cytoskeleton for multiple purposes, like   facilitating intracellular movement and host cell exit. Finally, functions as   its own regulator through autocatalytic activity as well as through phosphorylation   of its inhibitor, ABI1.

Subunit:

Interacts with PSMA7. Interacts with CTTN.

Subcellular   Location:

Cytoplasm, cytoskeleton.

Tissue   Specificity:

Widely expressed.

Post-translational   modifications:

Phosphorylated at Tyr-261 by ABL1 in response to   oxidative stress. Phosphorylated by PDGFRB.

Polyubiquitinated. Polyubiquitination of ABL2   leads to degradation.

Similarity:

Belongs to the protein kinase superfamily. Tyr   protein kinase family. ABL subfamily.

Contains 1 protein kinase domain.

Contains 1 SH2 domain.

Contains 1 SH3 domain.

Gene   ID:

27