中/英文名称：

血管紧张素转换酶2抗体/ Anti-ACE2

别名：

ACE-2; ACE 2; Angiotensin converting enzyme 2;   ACE related carboxypeptidase; ACEH; Angiotensin converting enzyme homolog;   Angiotensin converting enzyme like protein; Angiotensin I Converting Enzyme   (peptidyl dipeptidase A) 2; Angiotensin I converting enzyme 2; DKFZP434A014;   EC 3.4.17; OTTHUMP00000022963; angiotensin-converting enzyme 2 precursor;   ACE2_HUMAN; Angiotensin-converting enzyme 2; ACE-related carboxypeptidase;   Angiotensin-converting enzyme homolog; Metalloprotease MPROT15; Processed   angiotensin-converting enzyme 2.

产品编号：

zy10011

规格：

0.1ml 、0.2ml

抗体来源：

Rabbit

浓    度：

1mg/ml

缓冲液：

0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1%   Sodium azide；Reconstitute with 0.1ml sterile distilled water.

克隆类型：

Polyclonal

亚 型：

IgG

免 疫 原：

KLH conjugated synthetic peptide derived from   human ACE2 C-terminu

交叉反应：

Human, Mouse, Rat, Dog, Pig, Sheep

状态：

Lyophilized or Liquid

分 子 量：

Predicted molecular weight 87kDa

纯化方法：

affinity purified by Protein A

运输与储存

运输:

The product is shipped at ambient temperature.   Upon receipt, store it immediately at the temperature recommended below.

储存:

Use a manual defrost freezer and avoid repeated   freezethaw cycles.

1 month from date of receipt, 2 to 8℃, reconstituted.

6 months from date of receipt, -20 to -70℃, reconstituted.

12 months from date of receipt, -20 to -70℃as supplied.

When reconstituted in sterile pH 7.4 0.01M PBS or   diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

产品应用

应用:

WB=1:100-500    ELISA=1:500-1000    IP=1:20-100    IHC-P=1:100-500  IHC-F=1:100-500  IF=1:100-500
  Not yet tested in other applications.
  Optimal working dilutions must be determined by the end user.

背景:

The protein encoded by this gene belongs to the   angiotensin-converting enzyme family of dipeptidyl carboxydipeptidases and   has considerable homology to human angiotensin 1 converting enzyme. This   secreted protein catalyzes the cleavage of angiotensin I into angiotensin   1-9, and angiotensin II into the vasodilator angiotensin 1-7. The organ- and   cell-specific expression of this gene suggests that it may play a role in the   regulation of cardiovascular and renal function, as well as fertility. In   addition, the encoded protein is a functional receptor for the spike   glycoprotein of the human coronaviruses SARS and HCoV-NL63. [provided by   RefSeq, Jul 2008].

其他:

Function:

Carboxypeptidase which converts angiotensin I to   angiotensin 1-9, a peptide of unknown function, and angiotensin II to   angiotensin 1-7, a vasodilator. Also able to hydrolyze apelin-13 and   dynorphin-13 with high efficiency. May be an important regulator of heart   function. In case of human coronaviruses SARS and HCoV-NL63 infections, serve   as functional receptor for the spike glycoprotein of both coronaviruses.

Subunit:

Interacts with ITGB1. Interacts with SARS-CoV and   HCoV-NL63 spike glycoprotein.

Subcellular   Location:

Processed angiotensin-converting enzyme 2:   Secreted.

Cell membrane; Single-pass type I membrane   protein.

Tissue   Specificity:

Expressed in endothelial cells from small and   large arteries, and in arterial smooth muscle cells. Expressed in lung   alveolar epithelial cells, enterocytes of the small intestine, Leydig cells   and Sertoli cells (at protein level). Expressed in heart, kidney, testis, and   gastrointestinal system.

Post-translational   modifications:

N-glycosylation on Asn-90 may limit SARS   infectivity.

Proteolytic cleavage by ADAM17 generates a   secreted form.

Belongs to the peptidase M2 family.

Similarity:

Belongs to the peptidase M2 family.

Gene   ID:

59272

ACE-2的分布范围比较局限，ACE2主要在心脏、肾脏、睾丸中表达显著， 近来人们发现ACE2也分布在胃肠道、脑和肺脏中。

有关学者在研究心脏和肾脏中发现，ACE2在心肌缺血、肾功能衰竭、动脉粥样硬化和糖尿病并发症中，ACE2对血管紧张素产生和降解过程中有一定的生理作用。

特别是对ACE2在具有生理活性的-活性肽产生过程中的作用更值得进一步研究。 ACE2的发现为心血管病和肾脏病研究开辟了新天地，并提供了新的治疗靶点，可能导致未来心血管疾病治疗策略的改变。