中/英文名称：

脂联素受体2抗体/ Anti- Adiponectin Receptor 2

别名：

Adipo R2; Progestin and adipoQ receptor family   member II; Adipor2; PAQR2; ADR2_HUMAN.

产品编号：

zy10025

规格：

0.1ml    0.2ml

抗体来源：

Rabbit

浓    度：

1mg/ml

缓冲液：

0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1%   Sodium azide；Reconstitute with 0.1ml sterile distilled water.

克隆类型：

Polyclonal

亚 型：

IgG

免 疫 原：

KLH conjugated synthetic peptide derived from human   Adiponectin receptor 2 (315-340aa)

交叉反应：

Human, Mouse, Rat, Dog, Pig

状态：

Lyophilized or Liquid

分 子 量：

Predicted molecular weight 44kDa

纯化方法：

affinity purified by Protein A

运输与储存

运输:

The product is shipped at ambient temperature.   Upon receipt, store it immediately at the temperature recommended below.

储存:

Use a manual defrost freezer and avoid repeated   freezethaw cycles.

1 month from date of receipt, 2 to 8℃, reconstituted.

6 months from date of receipt, -20 to -70℃, reconstituted.

12 months from date of receipt, -20 to -70℃as supplied.

When reconstituted in sterile pH 7.4 0.01M PBS or   diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

产品应用

应用:

WB=1:100-500    ELISA=1:500-1000    IP=1:20-100    IHC-P=1:100-500  IHC-F=1:100-500  IF=1:100-500
  Not yet tested in other applications.
  Optimal working dilutions must be determined by the end user.

背景:

The adiponectin receptors, ADIPOR1 (MIM 607945)   and ADIPOR2, serve as receptors for globular and full-length adiponectin (MIM   605441) and mediate increased AMPK (see MIM 602739) and PPAR-alpha (PPARA;   MIM 170998) ligand activities, as well as fatty acid oxidation and glucose   uptake by adiponectin (Yamauchi et al., 2003 [PubMed 12802337]).[supplied by   OMIM, Mar 2008]

其他:

Function:

Receptor for globular and full-length adiponectin   (APM1), an essential hormone secreted by adipocytes that acts as an   antidiabetic. Probably involved in metabolic pathways that regulate lipid   metabolism such as fatty acid oxidation. Mediates increased AMPK, PPARA   ligand activity, fatty acid oxidation and glucose uptake by adiponectin. Has   some intermediate-affinity receptor activity for both globular and   full-length adiponectin.

Subunit:

May form homo and heteromultimers.

Subcellular   Location:

Membrane; Multi-pass membrane protein.   Note=Localized to the cell membrane and intracellular organelles.

Tissue   Specificity:

Highly expressed in skeletal muscle, liver and   placenta. Weakly expressed in brain, heart, colon, spleen, kidney, thymus,   small intestine, peripheral blood leukocytes and lung.

Similarity:

Belongs to the ADIPOR family.

Gene   ID:

79602

脂联素与受体结合后具有增强胰岛素敏感性，抗高血糖，抗动脉粥样硬化等生物学效应，任何增加或减少脂联素及其受体表达的方法都影响这些疾病的发生和发展。脂联素受体-1(AdipoR1和AdipoR2)同属于PAQR家族，具有七次跨膜蛋白的特有结构。

Tissue/cell: rat pancreas   tissue; 4% Paraformaldehyde-fixed and paraffin-embedded;
  Antigen retrieval: citrate buffer ( 0.01M, pH 6.0 ), Boiling bathing for   15min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30min;   Blocking buffer (normal goat serum) at 37℃ for 20 min;
  Incubation: Anti-Adiponectin Receptor 2 Polyclonal Antibody, Unconjugated   1:200, overnight at 4°C, followed by conjugation to the secondary antibody and   DAB staining

Tissue/cell: human rectal   tissue; 4% Paraformaldehyde-fixed and paraffin-embedded;
  Antigen retrieval: citrate buffer ( 0.01M, pH 6.0 ), Boiling bathing for   15min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30min;   Blocking buffer (normal goat serum) at 37℃ for 20 min;
  Incubation: Anti-Adiponectin Receptor 2 Polyclonal Antibody, Unconjugated   1:300, overnight at 4°C, followed by conjugation to the secondary antibody   and DAB staining