中/英文名称：

活性依赖的神经保护肽抗体/ Anti-   ADNP

别名：

Activity dependent neuroprotective protein;   Activity dependent neuroprotector; ADNP; NAP; KIAA0784

产品编号：

zy10029

规格：

0.1ml    0.2ml

抗体来源：

Rabbit

浓    度：

1mg/ml

缓冲液：

0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1%   Sodium azide；Reconstitute with 0.1ml sterile distilled water.

克隆类型：

Polyclonal

亚 型：

IgG

免 疫 原：

KLH conjugated synthetic peptide derived from   human ADNP

交叉反应：

Human, Mouse, Rat, Chicken, Dog, Cow

状态：

Lyophilized or Liquid

分 子 量：

Predicted molecular weight 114kDa

纯化方法：

affinity purified by Protein A

运输与储存

运输:

The product is shipped at ambient temperature.   Upon receipt, store it immediately at the temperature recommended below.

储存:

Use a manual defrost freezer and avoid repeated   freezethaw cycles.

1 month from date of receipt, 2 to 8℃, reconstituted.

6 months from date of receipt, -20 to -70℃, reconstituted.

12 months from date of receipt, -20 to -70℃as supplied.

When reconstituted in sterile pH 7.4 0.01M PBS or   diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

产品应用

应用:

WB=1:100-500    ELISA=1:500-1000    IP=1:20-100    IHC-P=1:100-500  IHC-F=1:100-500  IF=1:100-500
  Not yet tested in other applications.
  Optimal working dilutions must be determined by the end user.

背景:

The activity dependent neuroprotective protein   (ADNP) gene is frequently amplified in many neoplasias, including breast,   bladder, ovarian, pancreatic, and colon cancers. ADNP mRNA is abundantly   expressed in distinct normal tissues, and high expression levels were   encountered in malignant cells. ADNP is implicated in maintaining cell   survival, perhaps through modulation of p53. The encoded protein contains one   homeobox and nine zinc finger domains, suggesting that it functions as a   transcription factor.

其他:

Function:

Potential transcription factor. May mediate some   of the neuroprotective peptide VIP-associated effects involving normal growth   and cancer proliferation.

Subcellular   Location:

Nucleus (Potential).

Tissue   Specificity:

Widely expressed. Strong expression in heart,   skeletal muscle, kidney and placenta. In brain, expression is stronger in the   cerebellum and cortex regions. No expression detected in the colon. Strong   increase of expression in colon and breast cancer tissues.

Similarity:

Contains 9 C2H2-type zinc fingers.

Contains 1 homeobox DNA-binding domain.

Gene   ID:

23394

ADNP是一个潜在的转录调节因子，参与正常细胞与肿瘤细胞的增殖调控。

广泛分布于大脑、小脑等组织，在肺、肾、小肠以及睾丸等组织也有微弱的表达。对体外培养的glia缺失神经元细胞有保护作用.