中/英文名称：

腺苷酸激酶-1抗体   / Anti- Adenylate Kinase 1

别名：

Adenylate kinase isoenzyme 1; Adenylate kinase   soluble; AK 1; AK1; AK-1; ATP AMP transphosphorylase; Myokinase; KAD1_HUMAN;   ATP-AMP transphosphorylase 1.

产品编号：

zy10041

规格：

0.1ml   0.2ml   

抗体来源：

Rabbit

浓    度：

1mg/ml

缓冲液：

0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1%   Sodium azide；Reconstitute with 0.1ml sterile distilled water.

克隆类型：

Polyclonal

亚 型：

IgG

免 疫 原：

KLH conjugated synthetic peptide derived from   human Adenylate Kinase 1 (131-194aa)

交叉反应：

Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse,   Rabbit, Sheep, Goat, Monkey

状态：

Lyophilized or Liquid

分 子 量：

Predicted molecular weight 21kDa

纯化方法：

affinity purified by Protein A

运输与储存

运输:

The product is shipped at ambient temperature.   Upon receipt, store it immediately at the temperature recommended below.

储存:

Use a manual defrost freezer and avoid repeated   freezethaw cycles.

1 month from date of receipt, 2 to 8℃, reconstituted.

6 months from date of receipt, -20 to -70℃, reconstituted.

12 months from date of receipt, -20 to -70℃as supplied.

When reconstituted in sterile pH 7.4 0.01M PBS or   diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

产品应用

应用:

WB=1:100-500    ELISA=1:500-1000    IP=1:20-100    IHC-P=1:100-500  IHC-F=1:100-500  IF=1:100-500
  Not yet tested in other applications.
  Optimal working dilutions must be determined by the end user.

背景:

Adenylate kinase is an enzyme involved in   regulating the adenine nucleotide composition within a cell by catalyzing the   reversible transfer of phosphate group among adinine nucleotides. Three   isozymes of adenylate kinase have been identified in vertebrates, adenylate   isozyme 1 (AK1), 2 (AK2) and 3 (AK3). AK1 is found in the cytosol of skeletal   muscle, brain and erythrocytes, whereas AK2 and AK3 are found in the   mitochondria of other tissues including liver and heart. AK1 was identified   because of its association with a rare genetic disorder causing   nonspherocytic hemolytic anemia where a mutation in the AK1 gene was found to   reduce the catalytic activity of the enzyme. [provided by RefSeq, Jul 2008].

其他:

Function:

Catalyzes the reversible transfer of the terminal   phosphate group between ATP and AMP. Small ubiquitous enzyme involved in   energy metabolism and nucleotide synthesis that is essential for maintenance   and cell growth.

Subunit:

Monomer.

Subcellular   Location:

Cytoplasm.

DISEASE:

Defects in AK1 are the cause of hemolytic anemia   due to adenylate kinase deficiency (HAAKD) [MIM:612631].

Similarity:

Belongs to the adenylate kinase family.

Gene   ID:

203

AK1存在于人类红细胞上及某些组织中的具有遗传多态性的同工酶, 腺苷酸激酶催化 ATP，AMP 和 ADP 的转化，它是维持各种腺苷酸平衡的关键酶。因此，腺苷酸激酶就成为调控腺苷酸库大小的靶标分子。