Rabbit Anti- Adenylate Kinase 1
腺苷酸激酶-1抗体 / Anti- Adenylate Kinase 1
Adenylate kinase isoenzyme 1; Adenylate kinase soluble; AK 1; AK1; AK-1; ATP AMP transphosphorylase; Myokinase; KAD1_HUMAN; ATP-AMP transphosphorylase 1.
0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide；Reconstitute with 0.1ml sterile distilled water.
免 疫 原：
KLH conjugated synthetic peptide derived from human Adenylate Kinase 1 (131-194aa)
Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, Sheep, Goat, Monkey
Lyophilized or Liquid
分 子 量：
Predicted molecular weight 21kDa
affinity purified by Protein A
The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Use a manual defrost freezer and avoid repeated freezethaw cycles.
1 month from date of receipt, 2 to 8℃, reconstituted.
6 months from date of receipt, -20 to -70℃, reconstituted.
12 months from date of receipt, -20 to -70℃as supplied.
When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500
Adenylate kinase is an enzyme involved in regulating the adenine nucleotide composition within a cell by catalyzing the reversible transfer of phosphate group among adinine nucleotides. Three isozymes of adenylate kinase have been identified in vertebrates, adenylate isozyme 1 (AK1), 2 (AK2) and 3 (AK3). AK1 is found in the cytosol of skeletal muscle, brain and erythrocytes, whereas AK2 and AK3 are found in the mitochondria of other tissues including liver and heart. AK1 was identified because of its association with a rare genetic disorder causing nonspherocytic hemolytic anemia where a mutation in the AK1 gene was found to reduce the catalytic activity of the enzyme. [provided by RefSeq, Jul 2008].
Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Small ubiquitous enzyme involved in energy metabolism and nucleotide synthesis that is essential for maintenance and cell growth.
Defects in AK1 are the cause of hemolytic anemia due to adenylate kinase deficiency (HAAKD) [MIM:612631].
Belongs to the adenylate kinase family.
AK1存在于人类红细胞上及某些组织中的具有遗传多态性的同工酶, 腺苷酸激酶催化 ATP，AMP 和 ADP 的转化，它是维持各种腺苷酸平衡的关键酶。因此，腺苷酸激酶就成为调控腺苷酸库大小的靶标分子。