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ziyuBio offers hundreds of peptide modifications to meet your custom peptide needs. These peptide modifications can be used to create synthetic peptide with the exact conformation or characteristics needed for specific applications. Large numbers of modified amino acids are focus on post-translation modification (PTM) that naturally occur in vivo, while others are pharmacologically modified or stable isotope labeled. Additionally, tags, protein or oligonucleotides can be chemically conjugated to these peptides through ziyuBio. With many years of experience in providing modified peptide synthesis, we are your best choice for producing custom modified peptides on time and on budget. Our peptide modification services include but are not limited to the following:

  ■ Fluorophores and Quenchers: Emitting and Quenching dyes for FRET and other dyes

  ■ Attachment Chemistry: Linkers, Spacers and Polyethylene Glycol (PEG) modifications

  ■ Unnatural Amino Acids: D-stereoisomers, Unnatural and special amino acids

  ■ Post-translational Modifications (PTMs): Myristoylation, Palmitoylation, Glycosylation, Phosphorylation, Citrullination, Methylation, Succinylation

  ■ Isotopically Labeled (heavy) Amino Acids: Carbon 13 (C13), Nitrogen 15 (N15) and Deuterium (H2)

  ■ Immunogen Conjugation: Carrier protein conjugates, Lipids and Nucleic acids

  ■ Specialty Peptides: Stapled peptides, Cyclization, Dimerization and many others

  ■ Miscellaneous Modifications: Biotinylation, Carboxymethylation (CAM), Protecting group, Bioconjugation


All custom peptide synthesis and modification services includes:

  ■ HPLC Analysis

  ■ MALDI-TOF Mass Spectrometry

  ■ Certificate of Analyses

  ■ *Optional services: Amino acid Analysis and Sequencing

N-Terminus Modifications

Acetylation

Palmitoylation

Steroylation

Formylation

Succinylation

Biotin (short or long chain)

Fatty acid

Benzyloxycarbonyl

Fluorescent Dye Labeling

Myristoylation

Dinitrophenyl

Dabcyl, Dabsyl, Dansyl

Cinnamoylation

N-Methyl

DOTA & DTPA (metal Chelators)

Internal Modificaitons

Biotin

Dabcyl, Dabsy, Dansyl

Disulfide Cyclization

Fluorescein

Phosphorylation

 

C-Terminal Modifications

Amidation

p-Nitroanilide

AMC (for fluorogenic substrates)

EDANS

Ester (methyl, ethyl )

Hydrazide

Peptide Aldehydes

Substituted Amide

Thiol Esters

Branched MAP Peptide

 

 

Specialty Peptide Synthesis

Stapled Constrained Peptides

Heavy Isotope Labeling

Fluorescent Labeled Peptide

Unusual Amino Acids

PEGylation

Side-Chain Linked (β-Asp, γ-Glu, ε-Lys)

Glycosylation








 

This is not an exhaustive list and we will be pleased to discuss the synthesis of any modified peptide you require.

多肽修饰价格对照表

种类

修饰名称

价格(RMB

 

 

N端修饰或标记


5mg

10mg

20mg

乙酰化(Acetylation)

免费

免费

免费

脂肪酸(Pal, Myr)

500

600

800

N端生物素标记(Biotin

500

600

800

N-FITC  (Abs/Em=494/519nm)

700

900

1100

罗丹明B标记(Abs/Em=552/588nm)

700

900

1100

N-5-FAM  (Abs/Em=494/518nm)

900

1100

1300

DNP修饰    (Abs=348nm)

900

1100

1300

丹磺酰氯(dansyl  chloride,DNS

900

1100

1300

 

 

C端修饰或标记

酰胺化(Amidation,C-termainal)

免费

免费

免费

Biotin(赖氨酸侧链连接)

1100

1300

1500

C-FITC(赖氨酸侧链连接)

1100

1350

1500

AMC  (Abs/Em=360/405nm)

1100

1300

1500

pNA(pNitroanilide)

900

1100

1300

 

蛋白载体偶联

KLH(Keyholelimpetlleiiiocyanin,匙孔血蓝蛋白)

700

900

1100

BSA(Bovine serum albunin ,牛血清白蛋白)

700

900

1100

OVA(ovalbumin,卵清白蛋)

700

900

1100

 

磷酸化

Ser磷酸化(Phosphorylation-Serine)

800

1000

1200

Thr磷酸化(Phosphorylation-Threonine)

800

1000

1200

Tyr磷酸化(Phosphorylation-Tyrosine)

800

1000

1200

 

环肽

环化修饰(N-端和C-端首尾成环、LysAspGlu环化等)

900

1100

1300

二硫键环化(S-S

800

1000

1200

 

糖基化

Ser糖基化(D-GalNAC-glycosylated-Serine

600

800

1000

Thr糖基化(D-GalNAC-glycosylated-Threonine

600

800

1000

Tyr糖基化(D-GalNAC-glycosylated-Tyrosine

600

800

1000

Asp糖基化(D-GalNAC-glycosylated-Asparagine

600

800

1000

复合抗原肽(MAPs

4 支链 MAPs抗原肽

700

900

1100

8 支链 MAPs抗原肽

700

900

1100

 

 

特殊氨基酸

D-amino acids

×2AA

×2AA

×2AA

Cit,Aib,Abu,Ahx

×3AA

×3AA

×3AA

Lys(Ac)

×2AA

×2AA

×2AA

Lys(Me), Lys(Me2), Lys(Me3)

1400

1800

2000

说明:

1)   上表未列出修饰项目欢迎在线或来电咨询

2)   多肽总价格=裸肽(即无任何修饰)价格+修饰价格